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Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45

✍ Scribed by Zigui Chen; Leiping Fu; Rolando Herrero; Mark Schiffman; Robert D. Burk

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
358 KB
Volume
121
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high‐risk Ξ±7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations. Β© 2007 Wiley‐Liss, Inc.

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