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Identification of a novel CBFB-MYH11 fusion transcript in a patient with AML and inversion of chromosome 16

✍ Scribed by Springall, F H; Lukeis, R L; Tyrrell, V; Joshua, D E; Iland, H J


Book ID
110054016
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
80 KB
Volume
12
Category
Article
ISSN
0887-6924

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We used a newly established real-time RT-PCR assay for the quantification of the leukemia-specific CBFB/MYH11 transcripts in inv( 16)-positive acute myeloblastic leukemia. CBFB/MYH11 could be quantified over a five log range, with a detection limit of 10 molecules of a CBFB/MYH11 plasmid and a 1:10