Identification of a novel CBFB-MYH11 fusion transcript in a patient with AML and inversion of chromosome 16
β Scribed by Springall, F H; Lukeis, R L; Tyrrell, V; Joshua, D E; Iland, H J
- Book ID
- 110054016
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 80 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
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The cytogenetic findings in acute myeloid leukemia (AML) are a powerful prognostic indicator. Among these abnormalities, the World Health Organization has classified inv(16)(p13q22), which is closely associated with the M4E classification in the French-American-British system, as indicating a good-r
We used a newly established real-time RT-PCR assay for the quantification of the leukemia-specific CBFB/MYH11 transcripts in inv( 16)-positive acute myeloblastic leukemia. CBFB/MYH11 could be quantified over a five log range, with a detection limit of 10 molecules of a CBFB/MYH11 plasmid and a 1:10