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Identification of a new squamous cell differentiation marker and its suppression by retinoids

✍ Scribed by Reuben Lotan; Jack Pieniazek; Margaret D. George; Anton M. Jetten

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
998 KB
Volume
151
Category
Article
ISSN
0021-9541

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✦ Synopsis

Rabbit tracheobronchial epithelial cells (RbTE) can undergo squamous cell differentiation under defined culture conditions and, therefore, have been used as a model to study the regulation of squamous cell differentiation markers. In the present study, we identified a 20-kDa protein, designated rSQ20, in the serumfree growth medium conditioned by KbTE cells undergoing squamous cell differentiation. The protein was also found in extracts of squamous differentiated cells. rSQ20 was labeled by cells incubated with [35S]methionine but not with [3H]glu-

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