## Abstract Plasmepsin II (PMII), a malarial aspartic protease involved in the catabolism of hemoglobin in parasites of the genus __Plasmodium__, and renin, a human aspartic protease, share 35% sequence identity in their mature chains. Structures of 4‐arylpiperidine inhibitors complexed to human re
✦ LIBER ✦
Identification of a New Scaffold for Opioid Receptor Antagonism Based on the 2-Amino-1,1-dimethyl-7-hydroxytetralin Pharmacophore
✍ Scribed by Grundt, Peter; Williams, Ian A.; Lewis, John W.; Husbands, Stephen M.
- Book ID
- 115463781
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 116 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Development of a New Class of Inhibitors
✍
David A. Carcache; Simone R. Hörtner; Paul Seiler; François Diederich; Arnulf Do
📂
Article
📅
2003
🏛
John Wiley and Sons
🌐
German
⚖ 289 KB
A New Class of Inhibitors for the Malari
✍
David A. Carcache; Simone R. Hörtner; Andreas Bertogg; François Diederich; Arnul
📂
Article
📅
2003
🏛
John Wiley and Sons
🌐
German
⚖ 264 KB
## Abstract A new class of nonpeptidic inhibitors of the malarial aspartic protease plasmepsin II (PMII) with up to single‐digit micromolar activities (__IC__~50~ values) was developed by structure‐based __de novo__ design. The active‐site matrix used in the design was based on an X‐ray crystal str