Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats

✍ Scribed by Pércio S. Gulko; Yutaka Kawahito; Elaine F. Remmers; Van R. Reese; Jianping Wang; Svetlana V. Dracheva; Lynn Ge; Ryan E. Longman; Jennifer S. Shepard; Grant W. Cannon; Allen D. Sawitzke; Ronald L. Wilder; Marie M. Griffiths

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 962 KB
• Volume: 41
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/1529-0131(199812)41:12<2122::aid-art7>3.0.co;2-#

✦ Synopsis

Objective. To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type I1 collagen-induced arthritis (CIA).

Methods. We conducted a genome-wide scan to identify CLA regulatory quantitative trait loci (QTL) in an F, cross between DA (CIA highly susceptible) and ACI (CIA resistant) inbred rats immunized with homologous rat type I1 collagen (MI). These strains share the MHC/RTlaV1 haplotype required for susceptibility to RII-induced CIA.

Results. F, females had higher median arthritis scores than did males. Relative resistance in the males was determined by inheriting either a DA or an ACI Y chromosome and was independent of the source of the X chromosome. In addition, a major QTL was localized on chromosome 2 (Cia7, logarithm of odds score 4.6). Cia7 is in a region that shows linkage conservation with chromosomal regions that regulate autoimmune diabe-