Identification of a multicopy chromatin boundary element at the borders of silenced chromosomal domains

Functional analysis of DNA sequences loc

Functional analysis of DNA sequences located within a cluster of DNase U hypersensitive sites colocalizing with a MAR element at the upstream border of the chicken α-globin gene domain

✍ Sergey V. Razin; Kang Shen; Elena Ioudinkova; Klaus Scherrer 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB

We have cloned and sequenced a genomic DNA fragment of chicken containing a cluster of DNase I hypersensitive sites (DHS) located 11-15 kb upstream from the first gene of the ␣-globin gene domain and including a constitutive DHS flanked by two erythroid-specific ones. A 1.2-kb subfragment of the DNA