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Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR

✍ Scribed by Elizabeth R. Seaquist; Rolf Gruetter

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
391 KB
Volume
39
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The peak at 3.35 ppm in the ^1^H‐NMR spectrum characteristic for scyllo‐inositol may be a marker for cerebral pathology, although it has a well‐known constant concentration relative to myo‐inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo‐inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the ^13^C‐NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo‐inositol suggests that scyllo‐inositol metabolism may be regulated independently from myo‐inositol and that such concentrations are compatible with normal health.

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