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Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3

โœ Scribed by Zhiyong Ren; Larry A Cabell; Timothy S Schaefer; John S McMurray

Book ID
108477402
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
113 KB
Volume
13
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES

Structural basis for the binding of high
Structural basis for the binding of high affinity phosphopeptides to Stat3
โœ John S. McMurray ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 451 KB

## Abstract Signal transducer and activator of transcription 3 (Stat3) is constitutively active in a number of cancers where it participates in aberrant transcription of prosurvival, cell cycling, and angiogenesis genes. Since Stat3 initiates its signaling activity through binding of its SH2 domain