Mutant huntingtin and glycogen synthase
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Antonio Valencia; Patrick B. Reeves; Ellen Sapp; Xueyi Li; Jonathan Alexander; K
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Article
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2009
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John Wiley and Sons
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English
⚖ 525 KB
## Abstract Patients with Huntington's disease have an expanded polyglutamine tract in huntingtin and suffer severe brain atrophy and neurodegeneration. Because membrane dysfunction can occur in Huntington's disease, we addressed whether mutant huntingtin in brain and primary neurons is present in