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Identification of a dominant immunogenic epitope of the nucleocapsid (HBc) of the hepatitis B virus

✍ Scribed by J. A. Waters; T. P. Jowett; H. C. Thomas

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
467 KB
Volume
19
Category
Article
ISSN
0146-6615

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✦ Synopsis

Four monoclonal antibodies to hepatitis B core antigen are described. The antibodies bind to the same or a very closely related epitope. Antibodies to this dominant epitope are present in the sera of patients with either acute or chronic hepatitis B virus (HBV) infection. A high percentage of inhibition of the binding of these antibodies to the core antigen by these four monoclonal antibodies suggests that the core antigen has a restricted antigenicity in man. Radiolabeled or peroxidase labeled forms of these monoclonal antibodies can be used to assay IgM and total anticore in serum.

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