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Identification of a cytolytic protein in the coelomic fluid of Eisenia foetida earthworms

✍ Scribed by Martin Bilej; Lea Brys; Alain Beschin; Rudolf Lucas; Edilbert Vercauteren; Radka Hanušová; Patrick De Baetselier

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
590 KB
Volume
45
Category
Article
ISSN
0165-2478

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Lysenin, a novel protein that we isolated from the coelomic fluid of the earthworm Eisenia foetida, binds specifically to sphingomyelin (SM) among various phospholipids found in cell membranes, and causes cytolysis. The plasma membrane of mammalian spermatozoa is known to contain SM at relatively hi