𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Identification of a clinical subset of systemic lupus erythematosus by antibodies to the sm antigen

✍ Scribed by Donna M Winn; J Frederick Wolfe; Donald A Lindberg; Frank H Fristoe; Larry Kingsland; Dr. Gordon C Sharp

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
298 KB
Volume
22
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The clinical and renal histologic attributes of 135 systemic lupus erythematosus (SLE) patients with DNA and/or Sm antibodies were compared to determine if the presence of the Sm antibodies served as a marker for a specific subset of SLE. Although Raynaud's phenomenon was more frequent in patients with Sm antibodies (P < 0.005), serious central nervous system disease was over three times as common in patients with DNA antibodies (P < 0.005). Only one of 23 patients with Sm antibodies had diffuse proliferative glomerulonephritis on renal biopsy, whereas 6 of 14 patients with only DNA antibodies had this histologic finding (P = 0.01). The Sm antibody system may therefore identify a subset of SLE patients with milder central nervous system and renal disease.

πŸ“œ SIMILAR VOLUMES

The prevalence, onset, and clinical sign
The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
✍ Micah T. McClain; Melissa R. Arbuckle; Latisha D. Heinlen; Gregory J. Dennis; Jo πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 82 KB πŸ‘ 2 views

## Objective: To determine whether antiphospholipid antibodies (apl) occur before the diagnosis of systemic lupus erythematosus (sle) and before initial clotting events, and whether their presence early in the disease course influences clinical outcome. ## Methods: Serum samples obtained from 130

Sequential development of antibodies to
Sequential development of antibodies to specific sm polypeptides in a patient with systemic lupus erythematosus: evidence for independent regulation of antiβ€”double-stranded dna and anti-sm antibody production
✍ E. J. Ter Borg; G. Horst; E. Hummel; D. Jaarsma; P. C. Limburg; C. G. M. Kallenb πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 416 KB πŸ‘ 2 views

We describe a patient with systemic lupus erythematosus who, after a disease flare, sequentially produced antibodies to specific Sm polypeptides (demonstrated by counterimmunoelectrophoresis, immunoblotting, and RNA immunoprecipitation) concomitantly with the disappearance of anti-double-stranded DN