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Identification of a cardiac isoform of the murine calcium channel α1C (Cav1.2-a) subunit and its preferential binding with the β2 subunit

✍ Scribed by Manabu Murakami; Takayoshi Ohba; Yoichiro Takahashi; Hiroyuki Watanabe; Ichiro Miyoshi; Shinsuke Nakayama; Kyoichi Ono; Hiroshi Ito; Toshihiko Iijima

Book ID
116984272
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
588 KB
Volume
41
Category
Article
ISSN
0022-2828

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Functional cardiac L-type calcium channels are composed of the pore-forming ␣ 1C subunit and the regulatory ␤ 2 and ␣ 2 /␦ subunits. To investigate possible developmental changes in calcium channel composition, we examined the temporal expression pattern of ␣ 1C and ␤ 2 subunits during cardiac ontog