Identification of a Bohle iridovirus thymidine kinase gene and demonstration of activity using vaccinia virus
β Scribed by B. E. H. Coupar; S. G. Goldie; A. D. Hyatt; J. A. Pallister
- Book ID
- 106210441
- Publisher
- Springer Vienna
- Year
- 2005
- Tongue
- English
- Weight
- 958 KB
- Volume
- 150
- Category
- Article
- ISSN
- 1432-8798
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Transfer of the herpes simplex virus type 1 thymidine kinase (HSV-TK) gene into tumor cells using virus-based vectors in conjunction with ganciclovir (GCV) exposure provides a potential gene therapy strategy for the treatment of cancer. The possibility of using a novel targetable Sindbis virus expre
## Abstract Two technical hurdles, gene delivery and target specificity, have hindered the development of effective cancer gene therapies. In order to circumvent the problem of tumor specificity, the suicide gene, HSVβ1 thymidine kinase (HSVβTk), was modified with a complex 5β² upstreamβuntranslated