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IDENTIFICATION OF 5-HYDROXYTRYPTAMINE BINDING SUBSTANCES FROM RAT BRAIN STEM

✍ Scribed by David A. Johnson; Tae Mook Cho; Horace H. Loh

Book ID
111169624
Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
418 KB
Volume
29
Category
Article
ISSN
0022-3042

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High-affinity, specific 3H-5-hydroxytryptamine (5-HT) binding was analyzed in membrane homogenates of human frontal cortex, caudate, and globus pallidus. 5-HT1A and 5-HT1C binding sites were pharmacologically blocked using 100 nM 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT) and 100 nM mesulerg