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Identification of 3β-hydroxy-5α-cholest-6-ene-5-hydroperoxide in human oxidized LDL

✍ Scribed by D. Caruso; M.F. Rasetti; L. De Angelis; G. Galli

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
408 KB
Volume
79
Category
Article
ISSN
0009-3084

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✦ Synopsis

Oxidized LDL exhibits cytotoxic activity towards endothelial cells, which is thought to be mediated by the products derived also from cholesterol oxidation, mainly involving the B-ring. By LC-PB-EI-MS and El-MS/MS analysis, we have identified 3fl-hydroxy-5~-cholest-6-ene-5-hydroperoxide among the cholesterol oxidation products in LDL incubated with micromolar concentrations of copper ions.

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