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Identification of 13-cis retinoic acid in tissue extracts and its biological activity in rats

✍ Scribed by Zile, Maija H.; Emerick, R.J.; DeLuca, H.F.

Book ID
121895400
Publisher
Elsevier Science
Year
1967
Tongue
English
Weight
197 KB
Volume
141
Category
Article
ISSN
0304-4165

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The pharmacokinetics of three 13-cis-retinoic acid formulations were studied after intraperitoneal (ip) administration to rats. Rats were given ip injections of 2.5 mg of 13-cis-retinoic acid per 360 g of body weight; the drug was administered as an alkaline solution, suspended in corn oil, or as a