Identification in rats of N-nitrosonipecotic acid as a major urinary metabolite of the areca-nut alkaloid-derived nitrosamines, N-nitrosoguvacoline and N-nitrosoguvacine

Identification of the 1-cyano-3,4-epithi

Identification of the 1-cyano-3,4-epithiobutane-derived urinary mercapturic acid n-acetyl-s-(4-cyano-2-thio-1-butyl)-cysteine in male fischer 344 rats

✍ Jan L. Vansteenhouse; Judith S. Prescott; Steven A. Barker 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB 👁 2 views

1-Cyano-3,4-epithiobutane (CEB), a naturally occurring nitrile derived from cruciferous plants, causes nephrotoxicity in male Fischer 344 rats. Nephrotoxicity induced by CEB is dependent on glutathione (GSH) conjugation and bioactivation. Conjugation with GSH and subsequent metabolism leads to the f