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Identification, Characterization, and Inhibition of the Platelet ADP Receptors

โœ Scribed by Christian Gachet

Publisher
Carden Jennings Publishing
Year
2001
Tongue
English
Weight
105 KB
Volume
74
Category
Article
ISSN
0925-5710

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Molecular physiology of platelet ADP rec
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โœ Satya P. Kunapuli ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 118 KB ๐Ÿ‘ 1 views

Extracellular nucleotides have been implicated in a number of physiologic functions. Nucleotides act on cell surface receptors known as P2 receptors of which several subtypes have been cloned. Both ATP and ADP are stored in platelets and are released upon platelet activation. During vascular injury,

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ADP-induced platelet responses play an important role in the maintenance of hemostasis. There has been disagreement concerning the identity of an ADP receptor on the platelet surface. The chemical structure of 7-chloro-4-nitrobenz-2-oxa-l,3-diazole (NBD-CI) shows considerable resemblance to that of