Identification and quantitative determination of phenothiazine drugs in urine samples of psychiatric patients

✍ Scribed by A. P. De Leenheer

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 430 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630315

✦ Synopsis

A GLC method for the specific identification and quantitation of phenothiazine drugs excreted in urine at the microgram level is described. The phenothiazine drugs and less polar metabolites are isolated by two-phase extraction with ether as an organic extractant. Quantitative determination at the microgram level is done on an acetylated fraction of the alcoholic extract by GLC using a suitable internal standard. The compounds are also identified by examining an aliquot of the final alcoholic extract by TLC for supporting evidence of the GLC method's specificity.

Keyphrases 0 Phenothiazines-identification and determination in urine of psychiatric patients, GLC 0 Antipsychotic agents-GLC identification and determination of phenothiazine drugs in urine samples from psychiatric patients 0 GLC-identification and determination, phenothiazine drugs in urine, psychiatric patients Medicinal chemistry has led to the development of phenothiazine drugs containing a piperidyl or piperazinyl group in their structure. Because these more potent drugs are administered in lower amounts, the analyst faces the problem of their specific identification and quantitation at the microgram level.