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Identification and profiling of targeted oxidized linoleic acid metabolites in rat plasma by quadrupole time-of-flight mass spectrometry

✍ Scribed by Yuan, Zhi-Xin; Rapoport, Stanley I.; Soldin, Steven J.; Remaley, Alan T.; Taha, Ameer Y.; Kellom, Matthew; Gu, Jianghong; Sampson, Maureen; Ramsden, Christopher E.

Book ID
121232426
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
437 KB
Volume
27
Category
Article
ISSN
0269-3879

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## Abstract A qualitative and quantitative analysis of erlotinib (RO0508231) and its metabolites was carried out on rat tissue sections from liver, spleen and muscle. Following oral administration at a dose of 5 mg/kg, samples were analyzed by matrix‐assisted laser desorption ionization (MALDI) wit