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Identification and preliminary characterisation of a specific interleukin-1 beta binding protein

Book ID: 122627227
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 181 KB
Volume: 1
Category: Article
ISSN: 1043-4666
DOI: 10.1016/1043-4666(89)91173-3

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## Abstract Interleukin‐1 beta (IL‐1β) is a central mediator of inflammation and connective tissue destruction in rheumatoid arthritis. IL‐1β activates articular chondrocytes to produce matrix metalloproteinase‐1 (MMP‐1), an enzyme capable of dismantling the collagen scaffold of articular cartilage