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Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin

✍ Scribed by Igor Zelezetsky; Ulrike Pag; Nikolinka Antcheva; Hans-Georg Sahl; Alessandro Tossi


Book ID
116177215
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
278 KB
Volume
434
Category
Article
ISSN
0003-9861

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Pilosulin 1 is a synthetic 56-amino acid residue polypeptide that corresponds to the largest allergenic polypeptide found in the venom of the jumper ant Myrmecia pilosula. Initial experiments showed that pilosulin 1 lysed erythrocytes and killed proliferating B cells. Herein, we describe how flow cy