Kynurenic acid, a biologically active tryptophan metabolite, has been identified and measured in the rat brain and other organs using HPLC and GC/MS. Both the described methods required extraction of the compound in alkaline ethanol and initial purification on Dowex ion-exchange resins. The GC/MS ap
✦ LIBER ✦
Identification and Measurement of Oxindole (2-Indolinone) in the Mammalian Brain and Other Rat Organs
✍ Scribed by Raffaella Carpenedo; Vincenzo Carlà; Gloriano Moneti; Alberto Chiarugi; Flavio Moroni
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 103 KB
- Volume
- 244
- Category
- Article
- ISSN
- 0003-2697
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## Abstract Adenosine analogs such as 2‐chloroadenosine are potent cerebrovasodilators. Spin‐labeled MRI was used to investigate the spatial distribution, dose‐response, and timing of the effect of 2‐chloroadenosine on cerebral blood flow (CBF) after intraparenchymal injection into rat brain. Sprag