Identification and mapping ofLm-1, anIgh-linked locus for a murine alloantigen

✍ Scribed by Margot M. O'Toole; Roy Riblet; Melvin J. Bosma

• Publisher: Springer-Verlag
• Year: 1984
• Tongue: English
• Weight: 624 KB
• Volume: 20
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00364208

✦ Synopsis

Analyzing Igh congenic, Igh recombinant, and recombinant inbred mouse strains with a cytotoxic T-cell assay, we have identified and mapped an Igh-linked locus (Lm-1) that codes for a cell-surface alloantigen (Lm-1). Lm-1 maps 5 units telomeric to Pre-1 and is genetically distinct from previously described Igh-linked loci. The importance of Lm-1 and its possible relationship to other Igh-linked alloantigens is discussed.