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Identification and in vivo efficacy of small-molecule antagonists of integrin αvβ3 (the vitronectin receptor)

✍ Scribed by William H Miller; Richard M Keenan; Robert N Willette; Michael W Lark

Book ID: 114383286
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 452 KB
Volume: 5
Category: Article
ISSN: 1359-6446
DOI: 10.1016/s1359-6446(00)01545-2

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## Abstract The interaction between the arginine glycine and aspartic acid motif (RGD) of integrin ligands such as vitronectin and the integrin receptor αVβ3 in mediating cell attachment has been well described. Similarly, the ability of disintegrins, small RGD containing peptides, to inhibit cell