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Identification and hit-to-lead optimization of a novel class of CB1 antagonists

✍ Scribed by Jeffrey J. Letourneau; Patrick Jokiel; John Olson; Christopher M. Riviello; Koc-Kan Ho; Lihong McAleer; Jingchun Yang; Robert N. Swanson; James Baker; Phillip Cowley; Darren Edwards; Nick Ward; Michael H.J. Ohlmeyer; Maria L. Webb


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
766 KB
Volume
20
Category
Article
ISSN
0960-894X

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πŸ“œ SIMILAR VOLUMES


Hit-to-lead optimization of a series of
✍ Anette Graven Sams; Gitte KobberΓΈe Mikkelsen; Mogens Larsen; Lars Torup; Lise TΓΈ πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 475 KB

Chart 1. Structures and hA 2A and hA 1 binding affinities of istradefylline (KW-6002, 1), preladenant (SCH-420814, 2) and HTS hit 3.

ChemInform Abstract: Hit to Lead Optimiz
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v