Identification and high-resolution mapping of a constitutional 11q deletion in an infant with multifocal neuroblastoma
β Scribed by Yael Mosse; Joel Greshock; Allison King; Deepa Khazi; Barbara L Weber; John M Maris
- Book ID
- 117783045
- Publisher
- The Lancet
- Year
- 2003
- Tongue
- English
- Weight
- 94 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1470-2045
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## Abstract Somatically acquired chromosomal imbalances are a key feature of neuroblastoma, a heterogeneous pediatric solid tumor. Among these alterations, genomic amplification targeting the __MYCN__ oncogene and observed in about 25β30% of the cases, strongly correlates with advanced stage and po
Loss of heterozygosity (LOH) on chromosome arm 17p is the most common genetic aberration in childhood primitive neuroectodermal tumors (PNETs). To determine the frequency and extent of 17p deletions, 29 loci on 17p were investigated in 24 tumors by using restriction fragment length polymorphism (RFL