Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1α gene in a Korean family with MODY3
✍ Scribed by K.-A. Kim; K. Kang; Y.-I. Chi; I. Chang; M.-K. Lee; K.-W. Kim; S. E. Shoelson; M.-S. Lee
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 209 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0012-186X
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One form of maturity-onset diabetes of the young, Type 3 (MODY3), results from mutations in the gene coding for hepatocyte nuclear factor-1␣ (HNF-1␣), a transcription factor first described in the liver. MODY3 is characterized by a defective glucosestimulated insulin secretion. Earlier observations
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