Identification and determination of cystathionine sulfoxide and NAc-cystathionine sulfoxide in the urine of a patient with cystathioninuria using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

✍ Scribed by Jianying Zhang; Noriyoshi Masuoka; Toshihiko Ubuka; Hiroyuki Kodama

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 526 KB
• Volume: 30
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/jms.1190300914

✦ Synopsis

Abstract

Novel cystathionine metabolities, cystathionine sulfoxide and NAc‐cystathionine sulfoxide, were identified in the urine of a patient with cystathioninuria using liquid chromatography/mass spectrometry with an atmospheric pressure chemical ionization interface system. NAc‐cystathionine sulfoxide was discovered as a new metabolite of cystathionine in the urine of a cystathioninuric patient. The concentrations of cystathionine sulfoxide and NAc‐cystathionine sulfoxide in this urine were also determined for the first time using this method, and were 28.69 ± 0.44 and 10.51 ± 0.49 mg g^−1^ creatinine, respectively. Neither compound was detected in the urine of healthy subjects.