Identification and characterization oftenp, a gene transiently expressed before overt cell differentiation during neurogenesis
✍ Scribed by Yan, Run-Tao ;Wang, Shu-Zhen
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 596 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
The initiation of cellular differentinegative and thus postmitotic, yet without apparent ation in the vertebrate central nervous system is a differentiation such as the expression of microtubulecascade of regulated gene expression events involving both intrinsic and extrinsic factors. Currently, the moassociated protein ( MAP2 ) and neurofilament lecular events underlying the developmental transi-(NF68). When expressed in chicken embryonic fition from the cessation of cell proliferation to the onset broblast cells through transfection, Tenp protein was of cell differentiation during neurogenesis are still immunodetected in membrane fractions, implying poorly understood. We have identified a gene, tenp, that Tenp might be a membrane protein as predicted which is likely to play a role during the transition.
by a computer analysis of its primary sequence. Our tenp mRNA was detected in the developing retina and data suggested that tenp might be involved in an early brain, but not in the heart, kidney, or liver. Anatomineurogenic event that existed transiently after termically, cells expressing tenp formed a narrow strip at nal mitosis, yet before the overt differentiation of the boundary between the ventricular zone (consisting neural precursor cells. ᭧ 1998 John Wiley & Sons, Inc. of proliferating cells) and the intermediate zone (oc-