## Abstract The suitability of liquid chromatography tandem mass spectrometry (LC‐MS/MS) and gas chromatography mass spectrometry (GC‐MS) for the elucidation of fluoxymesterone metabolism has been evaluated. Electrospray ionization (ESI) and collision induced dissociation (CID) fragmentation in LC‐
Identification and characterization of urinary prenylamine metabolites by means of liquid chromatography-tandem mass spectrometry
✍ Scribed by S. Beuck; G. Sigmund; A. Koch; W. Schänzer; A. Pokrywka; D. Kwiatkowska; M. Thevis
- Book ID
- 112073690
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 456 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1942-7603
- DOI
- 10.1002/dta.1388
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug‐induced organ toxicities. Characterization of reactive metabolites is critical to designing new drug candidates with an improved toxic
The metabolism of the anti-inflammatory drug Celecoxib in rabbits was characterized using liquid chromatography (LC)/tandem mass spectrometry (MS/MS) with precursor ion and constant neutral loss scans followed by product ion scans. After separation by on-line liquid chromatography, the crude urine s
The metabolic products of pibutidine hydrochloride, a new H 2 -receptor antagonist, in human urine after oral administration of 40 mg/man were characterized by high-performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). Two-stage collision-induced d