Identification and characterization of PRKCBP1, a candidate RACK-like protein
โ Scribed by Sallyanne C. Fossey; Shunichi Kuroda; Jennifer A. Price; Joanne K. Pendleton; Barry I. Freedman; Donald W. Bowden
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 709 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0938-8990
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## Abstract Infantile neuronal ceroid lipofuscinosis (INCL; Batten disease) is a severe neurodegenerative disorder of childhood characterized by the accumulation of autofluorescent storage material in lysosomes. It is caused by mutation of the __CLN1/PPT1__ gene, which encodes the lysosomal enzyme
In a previous study [Nachaliel et al., 1993], we identified an RNA-binding protein (RBP) in FTO-2B rat hepatoma cells whose activity was stimulated upon the dissociation of a protein factor. We report in this article that the RBP is a complex protein of about 400 kDa, composed of RNA-binding subunit