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Identification and characterization of novel sequence variations in MECP2 gene in Rett syndrome patients

✍ Scribed by Leila Schuindt Monnerat; Aline dos Santos Moreira; Maria Carolina Viana Alves; Cibele Rodrigues Bonvicino; Fernando Regla Vargas


Book ID
113498857
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
637 KB
Volume
32
Category
Article
ISSN
0387-7604

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Variation in novel exons (RACEfrags) of
✍ Periklis Makrythanasis; Philipp Kapranov; Lucia Bartoloni; Alexandre Reymond; Sa πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 586 KB

The study of transcription using genomic tiling arrays has lead to the identification of numerous additional exons. One example is the MECP2 gene on the X chromosome; using 5'RACE and RT-PCR in human tissues and cell lines, we have found more than 70 novel exons (RACEfrags) connecting to at least on