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Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans

โœ Scribed by Gottschalk, Alexander; Almedom, Ruta B; Schedletzky, Thorsten; Anderson, Scott D; Yates, John R; Schafer, William R

Book ID
110031135
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
643 KB
Volume
24
Category
Article
ISSN
0261-4189

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## Abstract Infantile neuronal ceroid lipofuscinosis (INCL; Batten disease) is a severe neurodegenerative disorder of childhood characterized by the accumulation of autofluorescent storage material in lysosomes. It is caused by mutation of the __CLN1/PPT1__ gene, which encodes the lysosomal enzyme