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Identification and Characterization of Endogenous Langerin Ligands in Murine Extracellular Matrix

✍ Scribed by Tada, Yayoi; Riedl, Elisabeth; Lowenthal, Mark S; Liotta, Lance A; Briner, David M; Crouch, Erika C; Udey, Mark C


Book ID
110049359
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
270 KB
Volume
126
Category
Article
ISSN
0022-202X

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Human ICOS (huICOS) is a T cell-specific molecule structurally related to CD28 and CTLA-4 with potent co-stimulatory activities on T cell proliferation, cytokine induction and T cell help for B cells. We have now cloned and characterized murine ICOS (muICOS). muICOS mRNA of 1.5 kb and 3.3 kb encodes