Identification and Characterization of CYP2D6*56B, an Allele Associated with the Poor Metabolizer Phenotype
โ Scribed by Gaedigk, A; Eklund, J D; Pearce, R E; Leeder, J S; Alander, S W; Phillips, M S; Bradford, L D; Kennedy, M J
- Book ID
- 110020000
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 107 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0009-9236
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๐ SIMILAR VOLUMES
## Abstract ## Objective Risperidone is converted to 9โhydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of coโmedication on risperidone metabolism: the risperidone:9โhydroxyrisperidone concentration ratio (R:9โOHR ratio) and the sum of the
The purpose of this study was to clarify the pharmacokinetics of CYP2D6 substrates in female DA and Wistar rats, which are regarded as animal models of poor metabolizers and extensive metabolizers, respectively. In vivo pharmacokinetic and in vitro metabolic studies were conducted using metoprolol a