Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of intrahepatic bile ducts. Although the pathogenesis of this disease is still unknown, high titers of antimitochondrial autoantibodies (AMA) have long been recognized in patient sera. However, little is know
Identification and characterization of antimitochondrial autoantibodies in sera of patients with monoclonal gammopathies
β Scribed by B. Gilbrud; P. Weiss; R. Bakimer; Y. Shoenfeld
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 398 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0165-2478
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Primary biliary cirrhosis (PBC) is an autoimmune liver disease with unknown etiology. Patients with PBC have antimitochondrial autoantibodies (AMA) and additionally 50% of them have antinuclear antibodies (ANA). A 15-amino acid fragment (DRKASPPSGLWSPAY) from the Cterminal part of the nuclear envelo