The His-1 gene is developmentally expressed in the murine choroid plexus but is silenced in the adult brain. To test the hypothesis that the gene contains cis-acting elements that contribute to this repression, we have analyzed segments of the proximal promoter for negative regulatory sequences by t
Identification and characterization of a tissue-specific silencer element in the first intron of the human acid maltase gene
β Scribed by Bo Yan; Nina Raben; Nina Lu; Paul H. Plotz
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 166 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The epidermal growth factor receptor (EGFR) exhibits an inverse correlation with estrogen receptor (ER) expression in the majority of breast cancers, predicting a poor response to endocrine therapy and poor survival rate. Inappropriate overexpression of EGFR in breast cancer is associat
## Abstract Mice lacking transcription factor APβ2Ξ± exhibit defects in the formation of the head, body wall, heart, neural tube, eye, and limbs, reflecting important sites of APβ2Ξ± expression in the developing embryo. APβ2Ξ± is also expressed in the postnatal mammary gland and has been linked to tum
## Abstract Overβ and under expression of the 22 kDa peripheral myelin protein (PMP22) results in dysmyelinating peripheral neuropathies, such as CharcotβMarieβTooth disease type 1A (CMT1A) and hereditary neuropathy, with the liability to pressure palsies (HNPP). Expression of the PMP22 gene is dri
The rat osteocalcin gene encodes a 6-kD osteoblast-specific protein that is expressed postproliferatively. The developmental and steroid hormone responsive expression of the osteocalcin gene is transcriptiondlly regulated by a promoter with multiple basal and enhancer elements that exhibit activity