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Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase

✍ Scribed by Naomi Tanikawa; Yoshihiro Ohmiya; Hiroaki Ohkubo; Katsuyuki Hashimoto; Kenji Kangawa; Masami Kojima; Seiji Ito; Kikuko Watanabe

Book ID
115589579
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
124 KB
Volume
291
Category
Article
ISSN
0006-291X

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This study initially confirmed that, among prostaglandins (PGs) produced in bone, only PGE 2 has the potency to stimulate osteoclastogenesis and bone resorption in the mouse coculture system of osteoblasts and bone marrow cells. For the PGE 2 biosynthesis two isoforms of the terminal and specific en