Polycyclic aromatic hydrocarbons, e.g., benzo[a]pyrene (B(a)P) are known carcinogens/mutagens. These compounds may be metabolized by the P450 mixed function monooxygenase to more nucleophilic compounds which may form adducts to the cellular macromolecules, e.g., DNA, RNA, and proteins. We have used
β¦ LIBER β¦
Identification and Characterization of a Novel Benzo[a]pyrene-Derived DNA Adduct
β Scribed by Annette H. Fang; Wendy A. Smith; Paul Vouros; Ramesh C. Gupta
- Book ID
- 115587234
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 161 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Analysis of DNA adducts as indicators of human exposure to environmental levels of carcinogenic compounds represents an extreme challenge for trace analyses to chemists. At environmental exposure levels of benzo[__a__]pyrene, one can expect less than one adduct per 10^7^ base pairs, or
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