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Identification and characterization of a new family of high-affinity receptors for Escherichia coli heat-stable enterotoxin in rat intestinal membranes

✍ Scribed by Hugues, Michel; Crane, Marlys; Hakki, Shereen; O'Hanley, Peter; Waldman, Scott A.

Book ID
127325228
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
974 KB
Volume
30
Category
Article
ISSN
0006-2960

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## Abstract Guanylyl cyclase C (GC‐C), a transmembrane receptor for bacterial heat‐stable enterotoxin and the mammalian peptides guanylin and uroguanylin, mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling. In intestinal tumors, GC‐C expression is maintain