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Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE

✍ Scribed by Ashraf A Choglay; J.Paul Chapple; Gregory L Blatch; Michael E Cheetham

Book ID: 117520304
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 891 KB
Volume: 267
Category: Article
ISSN: 0378-1119
DOI: 10.1016/s0378-1119(01)00396-1

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## Abstract Citrate synthase (CS), the first and rate‐limiting enzyme of the tricarboxylic acid (TCA) cycle, plays a decisive role in regulating energy generation of mitochondrial respiration. Most mitochondrial proteins are synthesized in the cytoplasm as preproteins with an amino (N)‐terminal mit