Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac
β Scribed by Jamie E. Prior; Touraj Shokati; Uwe Christians; Ryan T. Gill
- Book ID
- 105952201
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 268 KB
- Volume
- 85
- Category
- Article
- ISSN
- 1432-0614
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## Abstract ## Background Different isoforms of Cytochrome P450 (CYP) metabolized different types of substrates (or drugs molecule) and make them soluble during biotransformation. Therefore, fate of any drug molecule depends on how they are treated or metabolized by CYP isoform. There is a need to
Cytochrome P-450 was detected in microsomes and presumably in cytosol of Neurospora crassa, and was found to be inducible by progesterone. In the microsomal fraction cytochrome b5 and NADPHcytochrome c reductase activities were measurable, too. Cytochrome P-450 of Neurospora crassa is inhibited by S