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Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism

✍ Scribed by Mikael Oscarson; Roman A. McLellan; Harriet Gullstén; José A.G. Agúndez; Julio Benı́tez; Arja Rautio; Hannu Raunio; Olavi Pelkonen; Magnus Ingelman-Sundberg

Book ID
117111602
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
132 KB
Volume
460
Category
Article
ISSN
0014-5793

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## Day Cytochrome P450 2A6 (CYP2A6) is a human enzyme best known for metabolizing tobacco-related compounds, such as nicotine, cotinine (COT), and nitrosamine procarcinogens. CYP2A6 genetic variants have been associated with smoking status, cigarette consumption, and tobacco-related cancers. Our ob