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Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

✍ Scribed by Waller, Zoë A.E.; Howell, Lesley A.; MacDonald, Colin J.; O’Connell, Maria A.; Searcey, Mark

Book ID: 121738008
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 503 KB
Volume: 447
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2014.03.117

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## Abstract To better understand the molecular mechanisms of cytochrome P450 1A2 (__CYP1A2__) regulation, we have characterized a region of the promoter (+3 to −176) that contains a single E‐box and an adjacent nuclear factor 1 (NF1)‐like DNA binding site. The E‐box was shown to specifically bind n