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Identification and Characterisation of 5-Hydroxytryptamine3 Recognition Sites in Human Brain Tissue

✍ Scribed by J. M. Barnes; N. M. Barnes; B. Costall; J. W. Ironside; R. J. Naylor


Book ID
111175367
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
658 KB
Volume
53
Category
Article
ISSN
0022-3042

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High-affinity, specific 3H-5-hydroxytryptamine (5-HT) binding was analyzed in membrane homogenates of human frontal cortex, caudate, and globus pallidus. 5-HT1A and 5-HT1C binding sites were pharmacologically blocked using 100 nM 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT) and 100 nM mesulerg