## Abstract 4โFluoroโ__N__โ{2โ[4โ(6โtrifluoromethylpyridinโ2โyl)piperazinโ1โyl]ethyl}benzamide is a full 5โHT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4โ[^18^F]fluoroโ__N__โ{2โ[4โ(6โtrifluoromethylpyridinโ2โyl)
Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist
โ Scribed by Swanson, Devin M.; Dubin, Adrienne E.; Shah, Chandra; Nasser, Nadia; Chang, Leon; Dax, Scott L.; Jetter, Michele; Breitenbucher, J. Guy; Liu, Changlu; Mazur, Curt; Lord, Brian; Gonzales, Lisa; Hoey, Kenway; Rizzolio, Michele; Bogenstaetter, Michael; Codd, Ellen E.; Lee, Doo H.; Zhang, Sui-Po; Chaplan, Sandra R.; Carruthers, Nicholas I.
- Book ID
- 120007523
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 308 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2623
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