Ab-initio folding simulations have been performed on three small proteins using a genetic algorithm-(GA-) based search method which operates on an all atom representation. Simulations were also performed on a number of small peptides expected to be independent folding units. The present genetic algo
Identification and ab initio simulations of early folding units in proteins
โ Scribed by Dimitri Gilis; Marianne Rooman
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 241 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0887-3585
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We present our predictions in the ab initio structure prediction category of CASP3. Eleven targets were folded, using a method based on a Monte Carlo search driven by secondary and tertiary restraints derived from multiple sequence alignments. Our results can be qualitatively summarized as follows:
## Abstract The neutral hydrolysis of formamide in water is a suitable reference to quantify the efficiency of proteolytic enzymes. However, experimental data for this reaction has only very recently been obtained and the kinetic constant determined experimentally is significantly higher than that