Identical distribution of the ?2-macroglobulin pentanucleotide deletion in subjects with alzheimer disease and controls in a German population

Phylogenetic analysis of the mitochondri

Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population

✍ Chagnon, Pierre; Gee, Mark; Filion, Mario; Robitaille, Yves; Belouchi, Majid; Ga 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 2 views

The activity of cytochrome oxidase (CO), the terminal enzyme of the mitochondrial electron transport chain, has been reported to be lower in the brains of Alzheimer disease (AD) patients. This suggests that a modification of mitochondrial DNA (mtDNA) may be responsible for this decrease of CO activi